Mixing: a sample's expression profile is the sum of the cell-type profiles (middle; each type's average expression) weighted by each type's proportion of cells (composition bar). Right: with a platform shift
(schematic), the same sample's actual bulk differs from its summed single cells, and deconvolution with the
single-cell profiles infers a composition that differs from the true one.
Drag a boundary in the composition bar to change the proportions.